Three pairs of comedians, dubbed the Red Nose Convoy, are heading from Kenya to Uganda delivering crucial supplies and seeing first-hand how money donated is changing lives.
The three twosomes are Reggie Yates (not sure if he counts as comedian but that's what the Comic Relief says) and Chewing Gum star Michaela Coel, David Baddiel and Hugh Dennis and Russell Kane and Katy Brand.
Watch a clip of what is in store for them here.
Picture: @rednoseday/Twitter